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Physiologically-based pharmacokinetic (PBPK) modeling and simulations

by Peters, Sheila Annie.

Additional authors: ebrary, Inc.

Published by : Wiley, (Hoboken, N.J. :) Physical details: xvii, 430 p. : ill.

Subject(s): Pharmacokinetics -- Mathematical models. | Drugs -- Design -- Mathematical models. | Electronic books.

Year: 2011

Online resources:

http://site.ebrary.com/lib/rucke/Doc?id=10558150
- An electronic book accessible through the World Wide Web; click to view

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Includes bibliographical references and index.

Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain.

Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries.

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