02784nam a2200385 a 4500 ebr10494674 CaPaEBR m u cr cn||||||||| 101015s2011 njuadf sb 001 0 eng d 2010043286 9780470449820 (cloth) 9781118001042 (oBook) 9781118001035 (ePDF) 9781118008980 (ePub) 9781118001035 (e-book) CaPaEBR CaPaEBR (OCoLC)746321023 RA1224.3 .B68 2011eb 616/.042 22 Applications of toxicogenomics in safety evaluation and risk assessment [electronic resource] / edited by Darrell R. Boverhof, B. Bhaskar Gollapudi. Hoboken, N.J. : John Wiley & Sons, c2011. xiii, 377 p., [8] p. of plates : ill. (some col.) Includes bibliographical references and index. Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan - -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach. Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Genetic toxicology. Toxicity testing. Health risk assessment. Electronic books. local Boverhof, Darrell R. Gollapudi, B. Bhaskar. ebrary, Inc. http://site.ebrary.com/lib/rucke/Doc?id=10494674 An electronic book accessible through the World Wide Web; click to view 129944 129944