02719nam a2200385 a 4500001001200000003000800012006001900020007001500039008004100054010001700095020002600112020002500138020001800163020002700181040002100208035002100229050002400250082001600274245012100290260003600411300005600447490005100503504005100554505122700605533015201832650003001984650003602014655002902050700001802079700001402097700002702111710001702138830005202155856012602207ebr10494679CaPaEBRm        u        cr cn|||||||||110224s2011    njuaf   sb    001 0 eng d  z  2011008300  z9781118092804 (ebook)  z9781118092811 (epub)  z9780470596685  z9781118092835 (e-book)  aCaPaEBRcCaPaEBR  a(OCoLC)74632426814aRS400b.M438 2011eb04a615/.1922200aMedicinal chemistry of nucleic acidsh[electronic resource] /cedited by Li-He Zhang, Zhen Xi, Jyoti Chattopadhyaya.  aHoboken, N.J. :bWiley,cc2011.  axxvi, 428 p., [8] p. of plates :bill. (some col.).1 aWiley series in drug discovery and development  aIncludes bibliographical references and index.0 aRecent advances in carbocyclic nucleosides : synthesis and biological activity / Jianing Wang, Ravindra K. Rawal, and Chung K. Chu -- Structures and functions of nucleic acids modified with S, Se, and Teand complexed with small molecules / Wen Zhang, Jia Sheng, and Zhen Huang -- Unraveling of the NAD cyclizing and calcium signaling functions of human CD38 / Hon Cheung Lee -- DNA and RNA binding small molecules / Shibo Li and Zhen Xi -- G-quadruplex DNA and its ligands in anticancer therapy / Zhi-shu Huang ... [et al.] -- Molecular modeling in nucleic acid targeted drug design / Lidan Sun ... [et al.] -- Structure of 10-23 DNAzyme in complex with the target RNA in silico : a progress report on the mechanism of RNA cleavage by DNA enzyme / Oleksandr Plashkevych and Jyoti Chattopadhyaya -- Labeling oligonucleotides towards the biomedical probe / Il Joon Lee and Byeang Hyean Kim -- Locked nucleic acid oligonucleotides towards clinical application / Rakesh N. Veedu and Jesper Wengel -- The pharmacokinetics researches of nucleic acid drugs / Shengqi Wang -- Inducible RNAi and drug target validation / Wei Xiong ... [et al.] -- SiRNA : the specificity and off-target effects -- Quan Du, Huang Huang, Zicai Liang.  aElectronic reproduction.bPalo Alto, Calif. :cebrary,d2013.nAvailable via World Wide Web.nAccess may be limited to ebrary affiliated libraries. 0aPharmaceutical chemistry. 0aNucleic acidsxTherapeutic use. 7aElectronic books.2local1 aZhang, Li-He.1 aXi, Zhen.1 aChattopadhyaya, Jyoti.2 aebrary, Inc. 0aWiley series in drug discovery and development.40uhttp://site.ebrary.com/lib/rucke/Doc?id=10494679zAn electronic book accessible through the World Wide Web; click to view