03314nam a2200361 a 4500 ebr10649214 CaPaEBR m u cr cn||||||||| 120801s2012 gw a sb 001 0 eng d 2012031110 9783110260366 (alk. paper) 9783110260373 (e-book) CaPaEBR CaPaEBR (OCoLC)828736053 QP609.K3 K35 2012eb 616.99/4042 23 Kallikrein-related peptidases [electronic resource] . Volume 1, Characterization, regulation, and interactions within the protease web / Viktor Magdolen ... [et al.], editors. Berlin : Walter de Gruyter, c2012. xvii, 409 p. : ill. Includes bibliographical references and index. Genomic structure of the KLK locus -- Single nucleotide polymorphisms in the human KLK locus and their implication in various diseases -- Evolution of Kallikrein-related peptidases -- Structural aspects of Kallikrein-related peptidases -- Molecular recognition properties of Kallikrein-related peptidases on synthetic and endogenous substrates -- Natural, engineered, and synthetic inhibitors of Kallikrein-related peptidases -- Kallikrein-related peptidases as pharmaceutical targets -- Expression of Kallikrein-related peptidases under (patho) physiological conditions -- Kallikrein-related peptidases within the proteolytic web -- Kallikrein-Kinin cascade: bioregulation by human tissue kallikrein 1 (HK1, KLK 1) -- Role of KLK4 in dental enamel formation. Kallikrein-related peptidases and semen -- Kallikrein-related peptidases and inhibitors of the skin -- Physiological and pathophysiological roles of Kallikrein-related peptidases in the central nervous system -- Kallikrein-related peptidases (KLKS), proteinase-mediated signaling and proteinase-activated receptors (PARS) -- Pathophysiology of Kallikrein-related peptidases in lung cancer -- Clinical relevance of Kallikrein-related peptidases in gastric and colorectal cancer -- Pathophysiology of Kallikrein-related peptidases in head and neck cancer -- PSA (prostate-specific antigen) and other Kallikrein-related peptidases in prostate cancer -- Cellular model systems to study the tumor biological role of Kallikrein-related peptidases in ovarian and prostate cancer -- Clinical relevance of Kallikrein-related peptidases in breast cancer -- Clinical relevance of Kallikrein-related peptidases in ovarian cancer -- MicroRNAs : a new control mechanism for Kallikrein-related peptidases in kidney and other cancers -- Genomic instability of the KLK-locus in cancer -- Kallikrein-related peptidases as biomarkers in personalized cancer medicine. Electronic reproduction. Palo Alto, Calif. : ebrary, 2013. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Kallikrein Genetics. Kallikrein Metabolism. Tumors Genetics. Proteolytic enzymes Metabolism. Electronic books. local Magdolen, Viktor. ebrary, Inc. http://site.ebrary.com/lib/rucke/Doc?id=10649214 An electronic book accessible through the World Wide Web; click to view 154521 154521