03201nam a2200337 a 4500 ebr10518751 CaPaEBR m u cr cn||||||||| 110714s2012 enkadf sb 001 0 eng d 2011029718 9781405196468 (hardcover alk. paper) 1405196467 9781444398281 (e-book) CaPaEBR CaPaEBR (OCoLC)773301453 RC935.M9 M87 2012eb 612.3 23 Muscle aging [electronic resource] : inclusion-body myositis and myopathies / edited by Valerie Askanas and w. King Engel. Oxford : Wiley-Blackwell, 2012. xii, 250 p., [8] p. of plates : ill. (some col.) Includes bibliographical references and index. Ageing of the human neuromuscular system : pathological aspects / W. King Engel and Valerie Askanas -- Aging of the human neuromuscular system : clinical considerations / W. King Engel and Valerie Askanas -- Aging of the human neuromuscular system : patient vignettes / W. King Engel, Shalini Mahajan, Valerie Askanas -- Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano -- Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin Davies -- Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. Drummond, Blake B. Rasmussen -- Pathogenesis of sporadic inclusion-body myositis / Valerie Askanas, W. King Engel, Anna Nogalska -- Inflammatory and autoimmune features of inclusion-body myositis / Marinos Dalakas -- Clinical symptoms, physical findings, and diagnostic investigations / Frank Mastaglia -- Pathologic diagnostic criteria of s-IBM and h-IBMS muscle biopsies / Valerie Askanas and W. King Engel -- Function and mutations of the GNE gene leading to DMRV/h-IBM, animal models, and potential treatments / May Malicdan, Satoru Noguchi, Ichizo Nishino -- Clinical and ethnic spectrum, laboratory data, and epidemiology of h-IBM due to GNE mutations / Zohar Argov, Ishizo Nishino, Ikiyo Nonaka -- Consequences of the h-IBM characteristic GNE mutations on muscle proteins in vivo and in vitro / Aldobrando Broccolini and Massimiliano Mirabella -- Function and structure of VCP mutations leading to h-IBM / Cezary Wojcik -- Clinical spectrum, including myopathy, Paget's disease, and fronto-temporal dementia : experimental models of VCP mutations, and potential treatments / Virginia Kimonis -- Animal models of h-IBM due to VCP mutation / Nisha M. Badders and Paul Taylor. Electronic reproduction. Palo Alto, Calif. : ebrary, 2013. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Inclusion body myositis. Electronic books. local Askanas, Valerie. Engel, W. King. ebrary, Inc. http://site.ebrary.com/lib/rucke/Doc?id=10518751 An electronic book accessible through the World Wide Web; click to view 236459 236459