03528nam a22003974a 4500001001200000003000800012006001900020007001500039008004100054010001700095015001900112016002000131016001800151020001800169020001500187040002100202035002100223050002300244082001800267245017600285260004300461300005700504504005100561505100500612505100901617533015202626650003902778650005602817650002302873655002902896700002202925700002302947710001702970856012602987999001703113ebr10346883CaPaEBRm        u        cr cn|||||||||070117s2007    dcuaf   sb    001 0 eng    z  2007002039  aGBA7401492bnb7 z1012974782DNLM7 z0137526052Uk  z9781555813031  z1555813038  aCaPaEBRcCaPaEBR  a(OCoLC)64685507314aQR177b.E59 2007eb04a616.9/04122200aEnzyme-mediated resistance to antibioticsh[electronic resource] :bmechanisms, dissemination, and prospects for inhibition /ceditors, Robert A. Bonomo, Marcelo Tolmasky.  aWashington, D.C. :bASM Press,cc2007.  axviii, 357 p., [8] p. of plates :bill. (some col.).  aIncludes bibliographical references and index.0 aOverview of aminoglycosides and enzyme-mediated bacterial resistance: clinical implications / Robert A. Bonomo -- Aminoglycoside antibiotics / Kanchana Majumder ... [et al.] -- Structural aspects of aminoglycoside-modifying enzymes / Gerard D. Wright and Albert M. Berghuis -- Aminoglycoside-modifying enzymes: characteristics, localization, and dissemination / Marcelo E. Tolmasky -- rRNA methylases and resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics / Marilyn C. Roberts -- [Beta]-lactamases: historical perspectives / Karen Bush and Patricia A. Bradford -- Resistance mediated by penicillin-binding proteins / Malcolm G. P. Page -- Inhibition of class A [beta]-lactamases / Samy O. Meroueh, Jooyoung Cha, And Shahriar Mobashery -- Class B [beta]-lactamases / Gian Maria Rossolini and Jean-Denis Docquier -- Crystal structures of class C [beta]-lactamases: mechanistic implications and perspectives in drug design / C. Bauvois and J. Wouters --0 aClass D [beta]-lactamases / Franck Danel, Malcolm G. P. Page, and David M. Livermore -- Kinetics of [beta]-lactamases and penicillin-binding proteins / Moreno Galleni and Jean-Marie Fr�ere -- The pharmaceutical industry and inhibitors of bacterial enzymes: implications for drug development / David M. Shlaes, Lefa Alksne, and Steven J. Projan -- [Beta]-lactamase inhibitory proteins / Zhen Zhang and Timothy Palzkill -- Active drug efflux in bacteria / J�urg Dreier -- Overview of dissemination mechanisms of genes coding for resistance to antibiotics / Marcelo E. Tolmasky -- Conjugative transposons / Louis B. Rice -- The dissemination of antibiotic resistance by bacterial conjugation / Virginia L. Waters -- Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics / Juan C. Alonso ... [et al.] -- Integrons and superintegrons / Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer -- The biological cost of antibiotic resistance / Dan I. Andersson ... [et al.].  aElectronic reproduction.bPalo Alto, Calif. :cebrary,d2013.nAvailable via World Wide Web.nAccess may be limited to ebrary affiliated libraries. 0aDrug resistance in microorganisms. 0aDrug resistance in microorganismsxGenetic aspects. 0aMicrobial enzymes. 7aElectronic books.2local1 aBonomo, Robert A.1 aTolmasky, Marcelo.2 aebrary, Inc.40uhttp://site.ebrary.com/lib/rucke/Doc?id=10346883zAn electronic book accessible through the World Wide Web; click to view  c43614d43614