02045nam a2200325 a 4500 ebr10558150 CaPaEBR m u cr cn||||||||| 110510s2011 njua sb 001 0 eng d 2011019939 9780470484067 (cloth) 9781118140383 (e-book) CaPaEBR CaPaEBR (OCoLC)794619804 RM301.5 .P48 2011eb 615/.7 23 Peters, Sheila Annie. Physiologically-based pharmacokinetic (PBPK) modeling and simulations [electronic resource] : principles, methods, and applications in the pharmaceutical industry / Sheila Annie Peters. Hoboken, N.J. : Wiley, c2011. xvii, 430 p. : ill. Includes bibliographical references and index. Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain. Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Pharmacokinetics Mathematical models. Drugs Design Mathematical models. Electronic books. local ebrary, Inc. http://site.ebrary.com/lib/rucke/Doc?id=10558150 An electronic book accessible through the World Wide Web; click to view 88391 88391