principles, methods, and applications in the pharmaceutical industry Peters, Sheila Annie. creator ebrary, Inc text bibliography Electronic books. nju Hoboken, N.J Wiley c2011 2011 monographic eng

electronic

electronic resource

xvii, 430 p. : ill. Modelling in the pharmaceutical industry -- Physiologically-based modelling -- A review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modelling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with pbpk models -- PBPK of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- PBPK modelling of populations -- PBPK models along the drug discovery and development value chain. Sheila Annie Peters. Includes bibliographical references and index. Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Pharmacokinetics Mathematical models Drugs Design Mathematical models RM301.5 .P48 2011eb 615/.7 http://site.ebrary.com/lib/rucke/Doc?id=10558150 http://site.ebrary.com/lib/rucke/Doc?id=10558150 CaPaEBR 110510 ebr10558150